Category Archives: Nootropics

Forskolin

Forskolin : a unique diterpene activator of cyclic AMP-generating systems.Forskolin is found in the roots of the plant Plectranthus barbatus (Coleus forskohlii). . This plant has been used since ancient times to treat heart disorders such as high blood pressure and chest pains, as well as respiratory disorders such as asthma.

Pyritinol

<img class="alignnone" src="http://www.pharmaoffshore.com/images/encephab.jpg" alt="http://www cheap diflucan generic.pharmaoffshore.com/images/encephab.jpg” width=”150″ height=”150″ />Pyritinol-HCl was tested for its impact on the cognitive functions of children with learning disabilities. This study is a contribution to scientific discussion on the complicated methodologic problems in evaluating the clinical efficacy of psychopharmacologic agents. Sixty-seven pupils of slow learner classes between the ages of 11 and 16 years were treated for 6 months with 300 mg pyritinol-HCl/24 hr or placebo under strict double-blind conditions. Drug intake was stimulated and controlled by means of intense psychosocial interaction with the mothers of the subjects. The dependence variables used to test medication effects were 22 parameters of cognitive performance measured in psychologic tests for perceptual and intellectual functions which were administered immediately before and after the medication phase. First the gainscores before and after treatment with pyritinol or placebo within the 22 cognitive parameters were statistically compared. In addition, an analysis of covariance on the corrected results of the second test (treating the results of first testing as covariates) and a two group discriminant analysis for overall differences were performed. None of the 22 parameters showed statistically significant treatment effects with respect to average performance (t (pyritinol – placebo) = 1.96 to 1.31), neither could the two groups be separated by discriminant analysis (Hotelling’s T2 = 35.4, df – 22 and 43, P = 0.465). With respect to a variability of gainscores, however, in four parameters there was a significantly higher variance in the pyritinol group (F = 1.85-2.33, P less than 0.05, less than 0.02, respectively). This fact may signify that pyritinol-HCl had different effects on different subjects. By means of prognostic stratification we therefore attempted to define objective criteria for a selection of subjects with probable positive treatment effects. None of the 15 tested criteria, such as body weight, age, perceptual handicaps, or reduced short term memory, IQ range, proved, however, to be critical for a prognosis of pyritinol effects within the present test population.

Pyritinol 50 mg improves memory and concentration not confirmed

http://www.ncbi.nlm.nih.gov/pubmed/1105370
is [5hydroxy-6-methyl-4-pyridine methanol] related compound (vitamin B6). It is a crystalline powder m. Promotes metabolism in the brain, but the effects can be seen after a long regular cycle (a few months). Increases levels of serotonin in the brain, increases the activity of transmigrates, stimulating brain activity. Formerly he had a wide application: atherosclerosis, post-stroke states, mental exhaustion, impaired memory and learning in children and the elderly. ia.

Dosage: 100-200 mg 2-3 times a day for several months. The species was introduced into medical practice in the early years of the 70s (under the name Enerbol).

Pyritinol was patented in 1961 (Winter 0, Schorre G .; E. Merck AG, Germany). Introduced into medical practice under the name Encephabol in 1963 by Merck.

Ginkgo Biloba

Ginkgo Biloba leafGinkgo Biloba is the most popular herbal nootropic and it is often sold as at is. Many scientific studies confirm the use of this herb is very safe to use. In particular, the leaves of the ginkgo tree are used and they have a long history of use in order to increase the memory and to treat blood disorders. Ginkgo Biloba contains ginkgolides and bilobalide, which appear only  in this plant, as well as a number of flavonoids (a class of plant secondary metabolites) and terpenoids (naturally occurring organic chemicals ). The effectiveness of Ginkgo is now used for treatment of the dementia and Alzheimer’s diseases. Researchers have found that this herb improves the mind and social behavior, as well as relieves depression. For this reason it is rightly called a  “smart drug”.

l theanine (L-Tianin)

l theanine: Amazing amino acid found almost entirely in black and green tea, which helps the mind to relax and also to protect the body from stress. It provides non-drowsy relaxation by crossing the blood-brain barrier in order to increase the level of relaxing neurotransmitters dopamine and GABA in the brain

L-Theanine with decaffeinated green tea. antidepressant

composition

1 capsule contains:

l theanine- 100 mg;
Green tea (decaffeinated) (Camellia sinensis) (Leaf) – 100 mg.

Action

Green tea – contains tannins (tannins), flavonoids, vitamin C, B1, B2, PP, A, pantothenic acid derivatives, caffeic acid, chlorophyll and other organic acids, purine alkaloids, amino acids (theanine, enzymes, a pectic substance essential oil and macro and micro elements. Biologically active substances cause its restorative, kapillyaroukreplyayuschee, vasodilator action.

Tianin – amino acid, a derivative of glutamic acid (glutamate). Tianin influences the metabolism and release of certain neurotransmitters in the brain, such as dopamine and serotonin.

Functional steps:

Penetrates into the brain through the blood-brain barrier, turning there in the gamma-aminobutyric acid (GABA). GAMK is as amino acid neurotransmitter and – one of the substances which ensure the transmission of nerve impulses between the brain cells.
Reduces anxiety and depression.
Stabilizes the emotional state during the pre-and during menopause.
Has anticoagulant activity.
Restores lost memory after a stroke.
Reduces blood sugar.
Lowers blood pressure.
Support cardiac function.

Tianin is not addictive and does not cause any other harm. It is a natural relaxant and tranquilizer that no man is intoxicating, it can be safely used in daytime.

Tianin permanently incorporated into the molecular structure of the leaf tea and conventional brewing not able to release it into the solution. Only a special technology in the factory allows you to get free Tianin in solution.
Indications

Depression, emotional disorders;
convulsions, epilepsy;
stroke (the recovery of speech and memory);
diabetes (decrease in blood sugar);
hypertension (pressure drop).

Instructions for use
Side effects and contraindications

Hypersensitivity of the components, pregnant and lactating women, as well as drivers, dispatchers and those of similar professions. Do not combine with taking drugs stimulating and hypotensive action. Before applying are encouraged to consult with your doctor.

(Aniracetam)

To improve the efficiency of the brain used a special group of pharmacological agents, called nootropics. This synthetic agents reception which allows increasing the stability of the brain to negative external shocks, improve attention, memory and mental clarity, as well as the ability to learn. Unlike stimulants – funds that have similar properties – nootropics do not give serious side effects (effects is very similar to the stimulant effect of drugs). One popular nootropics – drug Ampamet mainly active substance is Aniracetam . It is usually prescribed:

people actively engaged in mental activity, as well as neurological disorders, disorders of the brain, withdrawal syndrome, and so on. etc .;
older people with functional disorders of the brain and dementia, Alzheimer’s and Parkinson’s, etc. .;
children with intellectual disability;
athletes experiencing high during the competition nervous and mental stress, and in other cases.
In case of contact nootropa the body in the brain blood circulation improves and intensifies the bioelectrical activity (ie the transfer of excitation in the neurons). Due to this, and are activated mental (intellectual) function and improved exercise performance. Keep in mind that the impact of Ampameta and other nootropics is not immediately, but after a sufficiently long period of time after the start of the reception (1-6 months). Therefore it is very important to determine the competent dosage that can make a doctor. standard destination for adults – 1-2 tablets per day (1 – in the morning, 1 – day). Duration of the course is determined individually. We can buy Ampamet . Simply complete the online application on our website or call us pharmacy.

Modafinil

Modafinil
Pharmacological group: central stimulant, psychostimulant, nootropic. Pharmacological action: the treatment of narcolepsy, sleep apnea, and other sleep disorders. Effect on receptor alpha-1-adrenoceptor (agonist)

Description

Modafinil or benzhydrylsulfinylacetamide – central stimulant (psychostimulant). Substance approved by the FDA for the treatment of narcolepsy (a disease characterized by sudden and uncontrollable episodes of deep sleep, fatigue or excessive sleepiness), sleep apnea, and sleep disturbances caused by changes in the operating mode. Tests were conducted quality drug, including, as an agent for treating Alzheimer’s disease, depression, and attention deficit disorder. Modafinil belongs to a group of drugs known as evgeroiki (stimulants), promotes mental alertness and attention. One of the known mechanisms of action of these drugs is agonism alpha 1-adrenoceptor, resulting in drugs affect mood, increasing energy by increasing dopamine release in the central nervous system. This also leads to changes in the levels of GABA and glutamate. In studies of modafinil as a stimulant were shown superior efficacy compared with amphetamines. To begin with, that the substance is supposed to have a much lower potential for abuse due to the fact that its effects do not cause the same euphoria. Moreover, the drug has minimal effect on peripheral CNS stimulation (i.e., showing less side effects), has a minimal effect on blood pressure without causing disruption of sleep (hangover or without need to “catch” sleep), and, according to clinical trials, has a more reliable safety profile. It is used even in the United States armed forces as an energy stimulant for pilots and soldiers required to operate for long periods of time without sleep. This is not as strange as it may seem at first glance, as in the past, military pilots and soldiers are widely used Dexedrine (amphetamine) during long periods of lack of sleep. Soldiers applying modafinil often report that the drug helps them to maintain excellent cognitive function for up to 40 hours without sleep, and has fewer side effects than Dexedrine. Modafinil has been tested in recent combat situations, such as Afghanistan and Iraq, and perhaps in the future will receive official recognition as a special preparation for the military. Modafinil recently gained popularity among competitive athletes. They use it not only as a preparation for the “courage”, and as a stimulant, increasing performance and endurance. Such use is likely to be a surprise for the developers of this drug, as it was reported earlier that the “soft” drug increases alertness does not have strong stimulatory effects, and can not improve athletic performance. Recent studies contradict these statements. A study in Canada found that taking modafinil may provide benefits expressed sports. In a double blind study 15 male volunteers had taken the drug at a dose of 4 mg per kg body weight (equivalent to 200 mg for a person weighing 220 pounds) or placebo. Three hours after the meal were performed aerobic exercise on a bicycle ergometer at 85% of maximal aerobic power, until exhaustion. Taking modafinil men could exercise over much longer periods of time (up to 30% longer) and used more oxygen intake during exercise. Also reported a reduction in the perceived tension, resulting in marked increase in performance during training.

History

Modafinil was developed by Lafon Laboratories in France. In 1998, the drug was approved by the FDA for sale in the United States, where it is sold under the brand name Provigil. Modafinil is also found in the international market for these and certain other trade names, including Modiodal, Vigil, Alertec and Modasomil. Although the drug has a favorable safety profile in the United States for some time, he was considered a drug that can provoke possible abuse. Modafinil is currently included in Schedule IV controlled substances, along with Valium and Xanax. Thus, its use in non-medical purposes is limited by significant legal penalties for possession and importation of the drug. The drug has a fairly wide medical use, including sleep disorders associated with changes in the operating mode. The drug is often prescribed on prescription. In 2000-2004 Modafinil has become popular among competitive athletes before sports regulatory authorities have not begun to show concern about the use of the drug. In 2004, broke the doping scandal involving the company VALCO, when it became known that many of the athletes, which gave a positive result in the use of tetragidrogestrinona also used and Modafinil. After this, the IOC forbids the use of modafinil, and through a series of research methodology has been developed to detect this chemical in the urine. Now this test is part of the standard screening athletes before the Olympic competition. Most other international sporting bodies have followed the example of the IOC ban and testing of modafinil. Since then, the drug has lost its appeal as an “invisible” in tests, although it is still used by many athletes, not passing urine sample testing.

How Supplied

Modafinil often supplied as tablets of 100 mg and 200 mg each.

Structural characteristics of

Modafinil is a central nervous system stimulant, close to adrafinilu. It has the chemical name of 2 [(diphenylmethyl) sulfinyl] acetamide.

Modafinil side effects

Modafinil side effects usually associated with the stimulation of the central nervous system and may include nervousness, insomnia, tremors, euphoria, personality changes and agitation. The drug can also cause gastrointestinal disturbances such as nausea, vomiting, abdominal pain, dry mouth, anorexia, and headache. There may also be high blood pressure, heart palpitations or abnormal heart rhythm. In rare cases, it may manifest allergic rash, increased alkaline phosphatase, or in violation of voluntary movements.

Modafinil User

In clinical use for the treatment of excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea, the recommended dosage usually ranging from 200 to 400 mg per day. Dose may be taken once in the morning or in two divided doses (morning and noon). When used to improve physical performance, typical effective dosage is in the range of 100-400 mg. The drug is often mistaken for 2-3 hours before sporting events. Please note that side effects may depend on the dose. Often advised to start using modafinil at the lowest effective dose, and increase it to 50-100 mg for the reception to establish the optimum level. The scope of the drug are huge and, in fact, include any sports that focus on aerobic exercise and endurance. It is also excellent for athletes performing exercises for strength or speed in short intervals of repetitions (anaerobic exercise), such as shot put, pole vault and long jump. Modafinil is not popular drug of builders, since it does not directly affect the increase in muscle or reducing body fat. Some, however, believe that the drug is an effective stimulant pre-workout, especially during periods of fatigue or loss of physical activity after hard work or because of other reasons.

Buy Modafinil

Modafinil is currently to be found in more than two dozen countries. The drug, however, is not particularly popular on the black market and is not a lucrative target for counterfeiting. Modafinil is sold by prescription.

Phenotropil The Original Phenylpiracetam brand

Phenotropil The Original Phenlypiracetam brand manufacturer located in Russia.
The basic package
Phenotropil (Original Phenylpipracetam) 30 Tablets 100mg

one box contains 30 Tablets of Phenotropil 100mg of Phenylpiracetam active supplement

Composition: 1 tablet of Phenotropil contains :(phenylpiracetam ) 100 mg. Other assisting ingredients: potato starch, lactose, calcium stearate.

Pharmacological action: Fenotropil Phenylpiracetam is the czar of nootropic supplements. the Mechanism of action is a neuromodulator acts on most neurotransmitter systems in the brain. It expresses anti-amnesic effect the active integrative activity of the brain contributes to the consolidation of memory, improves concentration and mental performance ,increase motoric capabilities facilitates learning processes , accelerate the transfer of information between the hemispheres of the brain, increases the resistance of brain tissue hypoxia and toxic effects , has anticonvulsant activity and anxiolytic activity regulates the activation and inhibition of neural system. Phenotropil has a positive effect on metabolism and blood circulation of the brain and the phenyl molecule which is attached to the piracetam increase the efficiency of the piracetam by 30 to 60 time more in assisting the molecule to pass the brain blood barrier stimulates the redox processes , increases the energy potential by glucose utilization , improves regional blood flow in the ischemic areas of the brain .

Phenylpiracetam molecular C12H14N2O2