phenibut

PHARMACOLOGICAL ACTION
Nootropic agent is gamma-amino-beta-phenylbutyric acid hydrochloride. Facilitates GABA-mediated neurotransmission in the CNS (direct effect on GABA-receptors) also has anxiolytic, psychostimulant, antiplatelet and antioxidant effects.

Improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral blood flow (increases the volume and the linear velocity of cerebral blood flow, reduces the tone of cerebral blood vessels, improves microcirculation, has antiplatelet effect). Contributes to the reduction or disappearance of feelings of anxiety, tension, anxiety and fear, normalizes sleep, has some anticonvulsant effect.

Does not affect the choline and adrenergic receptors.

Latent period lengthens and shortens the duration and severity of nystagmus.

Reduces the appearance of fatigue and vazovegetativnye symptoms (including headache , a feeling of heaviness in the head, sleep disturbances, irritability, emotional lability), enhances mental performance.

Improves mental performance (attention, memory, speed and accuracy of the sensory-motor reactions).

In exchange reception improves physical and mental performance, improves memory, normalizes sleep; improves the condition of patients with motor and speech disorders. Patients asthenia from the first days of therapy improves health; increases the interest and initiative (motivation activities) without sedation and arousal. When applying after severe head injury increases the number of mitochondria in the perifocal areas and improves the course of bioenergetic processes in the brain.

When neurogenic lesions of the heart and stomach normalizes the process of lipid peroxidation. In the elderly does not cause congestion and excessive lethargy, relaxing aftereffect often absent. Improves microcirculation in the tissues of the eye, reduces the negative effect of ethanol on the CNS. Low toxicity.

PHARMACOKINETICS
Absorption is high well into all tissues of the body and across the BBB (brain tissue penetrates about 0.1% of the administered dose, and in young and elderly people are much more). Evenly distributed in the liver and kidneys. Metabolized in the liver – 80-95%, pharmacologically inactive metabolites. Not accumulates. After 3 h, begins to separate kidneys, the concentration in the brain tissue is not reduced, and it is found in the brain for a further 6 hours. About 5% is excreted unchanged by the kidneys partially – with bile.

DOSAGE
Inside, regardless of the meal. Dose, dosing frequency, and duration of treatment depend on the evidence, the patient’s age, tolerance. An adult dose ranges from 20

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