Hydrogen water, enriched with additional molecular hydrogen, has garnered significant attention in health and wellness. The surge of interest is based on numerous scientific studies showcasing hydrogen’s ability to combat oxidative stress and inflammation and offer therapeutic benefits for various diseases [1,10].
Antioxidant and Anti-inflammatory Effects
Oxidative stress, an imbalance between free radicals and antioxidants in the body, plays a critical role in the pathogenesis of various diseases. The antioxidative properties of hydrogen are suggested to counteract this oxidative stress . Studies have shown that molecular hydrogen can selectively reduce detrimental reactive oxygen species, protecting the cells from oxidative damage [1,10].
In addition to antioxidant benefits, molecular hydrogen has anti-inflammatory properties . This is especially beneficial in conditions characterized by chronic inflammation, such as obesity and metabolic syndrome . A study conducted on parasite-induced liver inflammation demonstrated the ability of hydrogen to mitigate inflammation significantly .
Impact on Neurological Health
Research has indicated the potential role of hydrogen-rich water in preserving neurological health. A study on mice showed that hydrogen consumption prevents stress-induced impairments in learning tasks during chronic physical restraint, offering implications for stress-related neurological disorders [14,15]. A clinical trial also noted improvements in mood, anxiety, and autonomic nerve function following the consumption of hydrogen-rich water .
Beneficial for Metabolic Syndrome and Diabetes
There’s compelling evidence pointing towards hydrogen water’s beneficial role in metabolic health. For instance, drinking hydrogen-rich water decreased serum LDL-cholesterol levels and improved HDL functions in patients with potential metabolic syndrome . Additionally, supplementation of hydrogen-rich water showed promising results in improving lipid and glucose metabolism in patients with type 2 diabetes . This is paramount, considering the rising global burden of metabolic disorders.
Protective Effects on Gastric Mucosa
Hydrogen-rich water might provide a protective barrier for the stomach. Studies have demonstrated that hydrogen-rich water reduces aspirin-induced gastric mucosal damage  and gastric injuries in general . These studies hint at hydrogen water’s potential role in maintaining gastrointestinal health.
Heart Health and Hydrogen Water
Cardiovascular disease remains a leading cause of mortality globally . Research indicates that treatment with a hydrogen molecule can attenuate cardiac dysfunction in streptozotocin-induced diabetic mice, thereby providing a protective role for heart health .
Anti-aging Potential and Regenerative Medicine
Emerging studies suggest that hydrogen could have applications in anti-aging and regenerative medicine. Hydrogen-rich water showed beneficial effects on aging periodontal tissues in rats, highlighting a potential anti-aging role . In regenerative medicine, hydrogen gas treatment was found to prolong the replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving their differentiation and paracrine potentials .
Overall, the current body of research provides compelling evidence of the beneficial effects of hydrogen water on human health. While these findings are promising, more clinical trials are needed to understand molecular hydrogen’s mechanisms and potential therapeutic applications fully. As science progresses, we may find ourselves harnessing the power of hydrogen to prevent and treat various medical conditions.
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